Indolplex is a dietary supplement which contains a bioavailable form of diindolylmethane (DIM®), a dietary indole found in cruciferous vegetables.



Indolplex is a dietary supplement which contains a bioavailable form of diindolylmethane (DIM), a dietary indole found in cruciferous vegetables. Research shows DIM promotes healthy estrogen metabolism by increasing the production of 2-hydroxyestrone estrogen metabolites over the undesirable 16-hydroxyestrone estrogen metabolites.*


Indolplex® with BR-DIM® Directions and/or Dosage

Take 2 tablets daily with food, may reduce to 1 tablet daily with food, or as recommended by your healthcare professional.


Do not use this product if you are pregnant, nursing, or attempting to become pregnant. A harmless but noticeable change in urine color may occur during usage of this product. If you are taking prescription drugs, consult your healthcare professional prior to use.Keep out of reach of children.


Patient Support

There is no Patient Support information available for this product


  • A. Diindolylmethane (pronounced: dye-indo-leel-methane), or DIM for short, as well as indole-3 carbinol (I3C) are plant nutrients found in broccoli, cauliflower, cabbage, and other related vegetables. Research has shown that DIM improves the way estrogen and other reproductive hormones are metabolized in the body.* However, the research on I3C has been mixed, with some studies showing benefits and other studies having negative results. As a dietary supplement, DIM provides the exact compounds that are found in vegetables. It's fully active and ready to be absorbed, while IC3 must first be synthesized into DIM after it is digested. When combined with vitamin E and phosphatidylcholine, DIM is highly absorbable. IC3, on the other hand, has an unpredictable absorption rate. The stability of IC3 is very low compared to DIM. Some research has shown IC3 may cause certain side effects, including stomach upset and dizziness; DIM has no known side effects. Therefore, Indolplex® with BR-DIM® features active DIM. There is no I3C in the product.

  • A. No, Indolplex® with BR-DIM® will not increase the production of testosterone or any other reproductive hormones. It does, however, balance the ratio of testosterone to estrogen by supporting healthy testosterone metabolism.† As a result, Indolplex® with BR-DIM® helps maximize your body's response to weight training and supports increased lean muscle and improved physical conditioning.†

  • A. Diindolylmethane (DIM) is a naturally occurring phytochemical found in cruciferous vegetables, such as raw broccoli. It takes two pounds of raw broccoli to equal the amount of DIM in one tablet of Indolplex® with BR-DIM®. The role of DIM in the body is to support healthy estrogen metabolism and hormonal balance, two factors known to prevent estrogen dominance.*

  • A. Indolplex® with BR-DIM® supports, restores, and maintains favorable estrogen metabolism and hormone balance for women in all stages of reproductive health.* This product has a patented delivery system to enhance absorption.* Indolplex® with BR-DIM® balances and optimizes the ratio of good estrogen metabolites (2-hydroxyestorgen) to bad estrogen metabolites (16-hydroxyestrogen).*

  • A. DIM, the key ingredient in Indolplex® with BR-DIM®, does not directly affect aromatase enzyme activity when taken as directed. However, there is research to suggest that it does influence aromatase indirectly. The 2-hydroxy estrogen metabolites that DIM has been shown to increase do have a limiting effect on aromatase activity.

  • A. The BioResponse-DIM in Indolplex® with BR-DIM® has been tested in both animal and clinical trials with regard to its potential effect on liver metabolism as it relates to oral contraceptive metabolism. The detailed animal and clinical testing have both shown that BioResponse-DIM does not influence the activity of the critical liver enzyme, CYP3A4, which is responsible for metabolizing ethinyl estradiol, the estrogen component in oral contraceptives. In contrast, other compounds have been found to increase the activity of this enzyme and have thus been associated with reducing the efficacy of oral contraceptives. Based on the desire of many women to use DIM in combination with oral contraceptives, BioResponse has conducted preliminary direct testing of combined use of BioResponse-DIM and oral contraceptives. Formal interaction testing with oral contraceptives has not yet been undertaken; however, preliminary human testing has indicated no evidence for interaction. In preliminary tests, normal levels of the birth control estrogen (ethinyl estradiol) were detected in the subjects' blood both prior to and while taking BioResponse-DIM 300 mg/day without significant change.  This preliminary evidence supports the effectiveness of oral contraceptives during supplemental use with BioResponse-DIM. Consistent with this evidence, women on oral birth control have been taking BioResponse-DIM without reported reduced efficacy or other adverse events.

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