Christopher Oswald, DC, CNS
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Clinical research, as well as empirical evidence suggests that the use of dehydroepiandrosterone (DHEA) can be very effective in supporting the healthy aging process.* There are many areas which may be supported including; bone health1 healthy mood2, and sexual health.3*
The question remains, “How much oral supplemental DHEA is appropriate?” DHEA dose responsiveness appears to depend upon the indication and the patient’s need. DHEA is a precursor to several other hormones which ultimately result in the formation of androgens such as androstenediol or testosterone and estrogens such as estrone, estradiol, and estriol. When supporting the healthy production of the aforementioned hormones, it is prudent to attend to the pleiotropic functions of these hormones as they affect a myriad of systems in the body. For this reason, I support and encourage periodic laboratory testing to confirm that the levels of DHEA remain in the optimal range. DHEA sulfate (DHEA-S) can also be measured in serum and saliva.
Prior to recommending DHEA or a DHEA dose, it is important to understand it is a contraindication to use in individuals with hormone-sensitivities and may interact with a variety of prescription medications. Side effects are uncommon, but women may experience changes to skin, hair, voice, menstrual periods, and other effects. Men may also have unwanted effects, while either gender may experience changes in sleep or mood.4
In order to understand the best approach to DHEA dosing, specific goals should be determined. Available research provides validation for a variety of dosing levels based on these goals.
In at least one instance, researchers chose a dose of 200 mg daily for up to 24 weeks.10*
As a quick recap, the steps when utilizing dehydroepiandrosterone (DHEA) are as follows:
REFERENCES
Last Updated:
03/03/2016
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