Integrative Blog

The Integrative Therapeutics blog is your destination for staying current on topics within the integrative medicine community.

T-Cell Differentiation and Intestinal Mucosal Barrier Function

// Amy Doyle, MS, CNS

The intestinal barrier encounters external stimuli from the environment on a daily basis. This barrier is comprised of a cellular layer, known as the epithelium, as well as a mucosal layer that consists of a sophisticated network of glycoproteins that function to protect the underlying single-celled layer. What follows is a discussion of the immune response within the mucosal layer and its influence on T-cell differentiation.

What Our Immune System Would Look Like Without Microflora

// Sarah Cook, ND

There is an undeniable connection between exposure to microflora (germs) and the function of immune systems. However, without microflora, immune systems would not exist. A deeper understanding of the mechanisms at play may inform individuals how, when, and why to use probiotics for therapeutic effect.

The Function of the Lungs

// Maxine Fidler, MS, ND

To best understand the challenges faced in regard to lung function, it is important to consider respiratory function, healthy lung function during cooler weather, and environmental factors which can influence function.

Let’s Talk About Snot: A Closer Look at Nasal Mucus

// Jessica Pizano, MS, CNS

Most of us rarely think about snot or mucus production. Yet, it is always present. What is the point of having this viscous substance?

Back to Basics: Macrophages and Natural Killer Cells

// Lauren Martin, MS, CNS

Our body’s immune system is a natural defense mechanism essential to survival. With such a significant role in health, the immune system is a common target of influence.

The HPA Axis

// Lise Alschuler, ND

The hypothalamic pituitary adrenal (HPA) axis is our central stress response system. The HPA axis is an eloquent and every-dynamic intertwining of the central nervous system and endocrine system. This system works in a fairly straight-forward manner. The HPA is responsible for the adaptation component of the stress response. This response is characterized by hypothalamic release of corticotropin-releasing factor (CRF). When CRF binds to CRF receptors on the anterior pituitary gland, adrenocorticotropic hormone (ACTH) is released. ACTH binds to receptors on the adrenal cortex and stimulates adrenal release of cortisol.

Alternative Sleep Patterns and the Sleep Cycle

// Lauren Martin, MS and Corey Schuler, MS, DC, CNS

Sleep is crucial to maintain a healthy lifestyle. Although the standard recommendation of 7- 8 hours of continuous sleep is familiar, history shows that the biphasic sleep patterns (having two sleep periods) may not be as uncommon as we think. Learn more about alternative sleep patterns, the sleep cycle, and what it could mean for patient care.

Adrenocorticotropic Hormone (ACTH) Resistance

// Christopher T. Arick, DC, MS

Clinicians may have heard the term ACTH resistance being tossed around clinical seminars and conferences related to adrenal function. These may all be descriptors or variants of ACTH resistance as an aspect of clinical presentation. Learn more about ACTH resistance and how it relates to lifestyle health, stress, and the regulation of the hypothalamic-pituitary-adrenal (HPA) axis.


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