New Curcumin Bioavailability Study: A Double-Blind, 3-Way Comparison

// Bob Doster, Ph.D.

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The clinical usefulness of curcumin, the main active constituent of turmeric (Curcuma longa), has been limited by its chemical instability at intestinal pH values, by its low water solubility, and by its poor oral bioavailability and quick conjugation and excretion. These properties have led to less than ideal conditions for therapeutic use. The consequence is that several human studies of curcumin have failed to demonstrate benefit, even at high doses, and its full clinical potential is as yet unrealized.

This study provides healthcare professionals with a much-needed bioavailability assessment of three popular, clinically-studied turmeric formulations.

A new study, published in the Journal of Nutritional Science and Vitaminology1, has compared three popular curcumin formulations. This double-blind, 3-way crossover study compared plasma curcumin levels after the consecutive single dose administration of three commercially available curcumin supplements.

The maximal level (Cmax) and total area under the curve (AUC) of plasma curcumin were assessed over the 24-hour period following administration.

  • Cmax: The authors report that the maximal plasma curcumin concentration (Cmax) of Theracurmin (287.2 ng/mL) was 5.6 - 10.7 times higher than that for the other two commercial preparations.* Notably, the plasma concentration of Theracurmin remaining at the end of the 24 hour test period (66.4 ng/mL) was higher than even the maximum values (Cmax) achieved by either of the other two commercial preparations at their peak.*
  • AUC: The authors report the Area Under the Curve (AUC) for plasma concentration over time as follows:
    • At 6 hours: AUC0-6h was reported to be 5.6 and 16.1-fold higher for Theracurmin relative to the other two formulations, respectively.*
    • At 24 hours: AUC0-24h was reported to be 4.6 and 11.0-fold higher for Theracurmin relative to the other two preparations, respectively.*

This study provides healthcare professionals with a much-needed bioavailability assessment of three popular, clinically-studied turmeric formulations. Click here for the full details of this study.

1Sunagawa Y, Hirano S, Katanasaka Y, et al. Colloidal Submicron-Particle Curcumin Exhibits High Absorption Efficiency - A Double-Blind, 3-Way Crossover Study. J Nutr Sci Vitaminol (Tokyo) 2015;61:37–44.
 

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†† For homeopathic products: these indications are based solely on traditional homeopathic use. They have not been evaluated by the Food & Drug Administration.
* For dietary supplements: this statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


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