Phosphatidylserine Found to Support a Healthy Stress Response*

// Integrative Therapeutics


Best known for its role in healthy cognitive function, research suggests that phosphatidylserine (PS) also supports a healthy stress response by helping to maintain cortisol levels within the normal range.*

Supplemental PS may support healthy cortisol levels and modulate some of the physiological changes that occur in the presence of stress.

Cortisol, often referred to as the “stress hormone,” is produced by the adrenal cortex as a response to physical and mental stress. An increase in cortisol boosts mental alertness and raises heart rate, blood pressure and blood sugar, triggering the well-known “flight or fight” response. While this response serves us well in times of crisis, increased or prolonged exposure to stress can undermine good health says Carnegie Mellon University psychologist Sheldon Cohen in a review of scientific literature which appeared in the Journal of the American Medical Association.

A series of clinical studies have found that taking supplemental PS reduces serum adrenocorticotropin (ACTH) and cortisol levels, as well as salivary cortisol levels following mental stress.* Derived from soy or sunflower lecithin, PS has also been found to blunt the effects of physical stress by decreasing blood levels of ACTH and cortisol as well as two other stress hormones, epinephrine and norepinephrine.*

These findings suggest that supplemental PS may support healthy cortisol levels and modulate some of the physiological changes that occur in the presence of stress.*


Cohen S, Janicki-Deverts D, Miller GE. Psychological distress and disease. JAMA. 2007;298(14):1685-1687.

Hellhammer J, Fries E, Buss C, et al. Effects of soy lecithin phosphatic acid and phyosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress. 2004;7(2):119-26.

Monteleone P, Beinat L, Tanzillo C, et al. Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinology. 1990;52(3):243-8.

Monteleone P, Maj M, Beinat L, et al. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharmacol. 1992;42(4):385-8.

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