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New Study Points to Benfotiamine’s Benefits

// Integrative Therapeutics


As a growing number of Americans pass their 50th birthday, there is an increasing focus on finding ways to maintain a healthy, active lifestyle. New research in the Clinical Journal of Pain suggests that benfotiamine, a water- and fat-soluble form of vitamin B1 (thiamine) that slows the formation of advanced glycation end-products (AGEs), may help adults maintain their mobility and daily activity.

Those in the supplement group saw improved scores at the conclusion of the trial compared to those in the placebo group.

What are advanced glycation end-products (AGEs)?

AGEs are complex compounds created when simple sugars crosslink with proteins or lipids through non-enzymatic reactions. The formation of AGEs is a normal part of the aging process; they are also formed outside the body when food is cooked, when tobacco is burned, and in other situations. AGEs irreversibly accumulate in cells and tissues of the body affecting their structure and function. Dietary and lifestyle interventions are of particular importance early in the accumulation cycle, to reduce the speed at which glycation reactions occur. 

Reduction of glycation and the formation of AGEs can help support:

  • blood glucose metabolism
  • blood vessel health and integrity
  • kidney structure and function
  • nerve structure and function
  • retinal structure and function
  • cellular aging


Benfotiamine Study Results

In a randomized, double-blind, placebo-controlled study, 30 subjects (average age of 57) were given either a supplement containing 50 mg of benfotiamine, 50 mg of pyridoxamine (a vitamer in the vitamin B6 family), and 500 mcg of methylcobalamin (vitamin B12) or a matching placebo three times a day for 24 weeks. Each participant was evaluated for joint function and mobility using standardized assessments at the beginning of the trial and again at the end. Those in the supplement group saw improved scores at the conclusion of the trial compared to those in the placebo group, with significant improvements in daily activity and mobility.

Garg S, Syngle A, Vohra K. Clin J Pain. 2013;29(8):717-24.


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