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Gluten Manager

Gluten Manager™ is uniquely designed digestive enzyme that includes both endopeptidase and exopeptidase activity in the form of Tolerase® G and dipeptidyl-peptidase IV (also known as DPP-IV). The combination of activity causes degradation at both the ends as well as the middle of the gluten molecule.*1-4 This makes a small gluten molecule proline peptide for easier and more complete digestion.

Form:
Capsule
Item #:
11956

  • 11956 - Gluten Manager
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$50.00
Suggested Retail Price (per unit)
Professional pricing is available upon sign in and authorization.
Count:  60 Capsules
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    • Dietary Considerations: Gluten Free Vegan Soy Free Dairy Free Wheat Free Sugar Free

    Similase® GFCF is a gluten and casein digestive enzymes to support the breakdown of gluten or casein.*Similase GFCF supports a gluten-free, casein-free lifestyle and helps relieve occasional indigestion, gas and bloating.*

About

Gluten Manager™ - Digestive Enzymes

Avoiding dietary gluten can be a challenge. In a study of individuals with very high sensitivity to gluten that were following a gluten free diet, 66% suspected unintended exposure.7 Gluten can cause immunological and opioid-like effects on the nervous system of sensitive individuals. As gluten is a protein, it is typically broken down into small amino acids. However, gluten is comprised of gliadin which is difficult to digest due to the long proline peptides.

Gluten Manager has dual mechanism-of-action digestive enzymes that hydrolyzes gluten at both the middle and end of the gluten molecule through the use of prolyl-endopeptidase (Tolerase® G) and dipeptidyl-peptidase IV enzyme activity (DPP-IV)†. The use of both digestive enzymes degrades the proline peptide into smaller chains that can be more completely digested.

  • Features microbial enzymes that are stable in acidic environments
  • Helps support the breakdown of gluten
  • Smaller peptide chains for easier digestion
Theoretical mechanism of action using Tolerase G & DPP-IV†

 

Tolerase® G is a trademark of DSM.

 

  1. Salden BN, Monserrat V, Troost FJ, et al. Randomised clinical study: Aspergillus niger-derived enzyme digests gluten in the stomach of healthy volunteers. Aliment Pharmacol Ther. 2015 Aug;42(3):273-85.
  2. Mitea C, Havenaar R, Drijfhout JW, et al. Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac disease. Gut. 2008 Jan;57(1):25-32.
  3. Stepniak D, Spaenij-Dekking L, Mitea C, et al. Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease. Am J Physiol Gastrointest Liver Physiol. 2006 Oct;291(4):G621-9.
  4. Ehren J, Morón B, Martin E, et al. A food-grade enzyme preparation with modest gluten detoxification properties. PLoS One. 2009 Jul 21;4(7):e6313.
  5. Montserrat V, Bruins MJ, Edens L, Koning F. Influence of dietary components on Aspergillus niger prolyl endoprotease mediated gluten degradation. Food Chem. 2015 May 1;174:440-5.
  6. Tack GJ, van de Water JM, Bruins MJ, et al. Consumption of gluten with gluten-degrading enzyme by celiac patients: a pilot-study. World J Gastroenterol. 2013 Sep 21;19(35):5837-47.
  7. J. A. Silvester, L. A. Graff, L. Rigaux, J. R. Walker, D. R. Duerksen. Alimentary Pharmacol Ther. 2016 Sept;44(6):612-619.

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†† For homeopathic products: these indications are based solely on traditional homeopathic use. They have not been evaluated by the Food & Drug Administration.
* For dietary supplements: this statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


© Integrative Therapeutics, LLC.