Integrative Blog

The Integrative Therapeutics blog is your destination for staying current on topics within the integrative medicine community.

Exploring the Alarm Stage of General Adaption Syndrome

// Lauren Martin, MS, CNS

The alarm stage of the General Adaption Syndrome is described as the sum of all non-specific systemic phenomena elicited by sudden exposure to stimuli to which the organism is quantitatively or qualitatively not adapted.1 Let’s explore the effects of the alarm stage on the body, defensive mechanisms, and what this means to overall wellbeing.

The Role of Cortisol

// Lise Alschuler, ND

I find myself thinking and talking about cortisol a lot these days. It’s actually a nice back to the future kind of thing as I remember getting very excited about cortisol when I was in school in the mid-90’s. One of my very first lectures was on the topic of stress, the hypothalamic-pituitary-adrenal (HPA) axis, and cortisol. After hacking my way through the jungles of clinical practice for the next 20 years, I find that I have made my way right back to cortisol.

Cortisol and Sleep: The HPA Axis Activity Connection

// Tori Hudson, ND

The hypothalamic-pituitary-adrenal (HPA) axis interacts with sleep in a multiplicity of ways and a growing body of research suggests reciprocal associations between sleep and activity of the HPA axis. Normal sleep architecture is characterized by cycles of light sleep, deeper slow-wave sleep and REM sleep. Light sleep includes stage 1 and stage 2 sleep. Stage 1 sleep has mixed frequency theta, slow rolling eye movements and slightly reduced eye movement and chin electromyography (EMG). Stage 2 has mixed frequency electroencephalogram (EEG). Deeper slow-wave sleep includes stages 3 and 4. Stage 3 sleep is characterized by 20-50% delta EEG and stage 4 has greater than 50% delta EEG.

The HPA Axis

// Lise Alschuler, ND

The hypothalamic pituitary adrenal (HPA) axis is our central stress response system. The HPA axis is an eloquent and every-dynamic intertwining of the central nervous system and endocrine system. This system works in a fairly straight-forward manner. The HPA is responsible for the adaptation component of the stress response. This response is characterized by hypothalamic release of corticotropin-releasing factor (CRF). When CRF binds to CRF receptors on the anterior pituitary gland, adrenocorticotropic hormone (ACTH) is released. ACTH binds to receptors on the adrenal cortex and stimulates adrenal release of cortisol.

Sleep and Athletic Performance

// Erin E. Ducat, DC, CSCS, CCSP and Corey Schuler, MS, DC, CNS

In any sport, successful performance requires a planned approach to training and recovery. Poor or inadequate sleep affects athletic performance, recovery, and may have systemic effects. Many studies have evaluated sleep deprivation, a prolonged period of sleep loss such as a whole night or longer; however, sleep restriction, the partial disturbance of the sleep-wake cycle, is more akin to real world experiences of athletes. The following article is a sample of the evidence of sleep restriction in athletes that can help decision-making regarding the use of sleep support habits and/ or agents.

Stress Response: Understanding Gender Differences in Dealing with Stress

// Corey Schuler, MS, DC, CNS

Assessing stress is complicated business. Many disciplines are asking profound and perhaps age-old questions about the differences between men and women and how they go about dealing with stress. Learn more about gender differences in dealing with stress now. 

“Smart” Sleep: How EMF (Electric and Magnetic Fields) and Non-Ionizing Radiation Sabotages Your Z’s

// Christy Williamson, MS

As you read this article, take a moment and consider the amount of radiation that is pulsing through your body. Wait…What? In today’s world, we are constantly bombarded with something called electric and magnetic fields (EMFs). Learn more about EMF and how it ties to many of the things you use today.  

Adrenocorticotropic Hormone (ACTH) Resistance

// Christopher T. Arick, DC, MS

Clinicians may have heard the term ACTH resistance being tossed around clinical seminars and conferences related to adrenal function. These may all be descriptors or variants of ACTH resistance as an aspect of clinical presentation. Learn more about ACTH resistance and how it relates to lifestyle health, stress, and the regulation of the hypothalamic-pituitary-adrenal (HPA) axis.

How Lavender (Lavandula angustifolia) Works

// Corey Schuler, MS, DC, CNS

Lavender (Lavandula angustifolia) is a member of the Lamiaceae (Mint) family. The purported therapeutic actions of lavender are as a carminative which means it affects gastrointestinal gas production.*  It also affects muscle tension  and mood.* Lavender is thought to dilate capillaries and increase blood circulation via topical application and inhalation.The mechanism of how oral lavender works, however, is a matter of conflict. Read about this conflict and more on how Lavender works.

Examining Stress: The HPA Axis & Sympathetic-Adrenal-Medullary System

// Corey Schuler

While the adrenal glands are often pointed to as responsible for handling the normal stress response, they may instead be target organs of two intersecting systems. The hypothalamus-pituitary-adrenal (HPA) axis is the endocrine response to stressors producing adrenocorticotropic hormone (ACTH) from the pituitary gland with measurable changes in levels of plasma cortisol and salivary cortisol as produced in the adrenal cortex. The sympathetic-adrenal-medullary system produces epinephrine and norepinephrine and measurable changes in heart rate are seen. It is important not to oversimplify this relationship as HPA responses habituate to repeated stress exposure. In effect, the body responds better and better to the same stressor. The sympathetic system shows rather uniform activation patterns with repeated stress exposure.1


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†† For homeopathic products: these indications are based solely on traditional homeopathic use. They have not been evaluated by the Food & Drug Administration.
* For dietary supplements: this statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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